jianfeng ge

Jianfeng studied bioengineering at Hebei University (2007-2011). After completing his undergraduate degree, Jianfeng joined Yaojiong Wu’s group in Tsinghua University (2011-2014) as a master to study cells therapy based on 3D cultured mesenchymal stem cells (MSCs)and investigate factors in safety of intracarotid cells transplantation, investigate the molecular mechanism of extracellular matrix for hair follicle regeneration. During his master in Tsinghua University, he was awarded national scholarship, then one of the best graduated master students and also university-level outstanding master thesis. Meanwhile he also submitted one patent.

From 2014 to 2018, he was a PhD student supervised by prof. Cord Brakebusch in BRIC, University of Copenhagen, where he focused on studying role of Rho GTPase in regulating myofibroblasts differentiation of MSCs. After he got his PhD degree, he joined Sakari Vanharanta’s group, MRC-CU, University of Cambridge, as a research associate to study the genetic vulnerabilities in VHL mutant quasi-normal cells by using CRISPR-cas9 based genome wide screening techniques, organoids model et al (2018-2022). Since then he joins the group of Daniel Munoz-Espin, in the Department of Oncology, University of Cambridge. Here he focuses on studying senolytic targets in drug induced senescent cancer cells by using CRISPR-cas9 genome wide screening technique.

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Selected publications

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• Saroor. Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma Richardson, Jianfeng Ge, Saiful Syafruddin, Alyson Speed, Evangelia Papachristou, Ludovic Wesolowski, Veronica Caraffini, Dora Bihary, Cissy Young, David Harrison, Grant Stewart, Anne Warren, Shamith Samarajiwa, Jason Carroll, Sakari Vanharanta.

Renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.

 Nature. 2022.

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• Mei Qi Kwa, Rafael Brando, Trong H Phung, Jianfeng Ge, Giuseppe Scieri, Cord Brakebusch.

MRCKa is dispensable for breast cancer development in the MMTV-PyMT model. 

Cells. 2021.

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• Jianfeng Ge, Laurent Burnier, Maria Adamopoulou, Matthias Schaks, Klemens Rottner, Cord Brakebusch.

RhoA, Rac1, Cdc42 differentially regulate myofibroblasts differentiation of mesenchymal stem cell. 

Journal of Biological Chemistry. 2018.

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• Wang, XS., Chen, HY., Tian, RY., Zhang, YL., Drutskaya, MS., Wang, CM., Ge, JF., Fan, ZM., Kong, DQ., Wang, XX., Cai, T., Zhou, Y., Wang, JW., Wang, JM., Wang, S., Qin, H., Jia, HH., Wu, Y., Liu, J., Nedospasov, SA., Tredget, EE., Lin, M., Liu, JJ., Jiang, YY., and Wu, YJ.

Macrophages induce AKT/beta-catenin-dependent Lgr5(+) stem cell activation and hair follicle regeneration through TNF. 

Nature Communications. 2018.

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• Wang, XX., Wang, XS., Liu, JJ., Cai, T., Guo, L., Wang, SJ., Wang, JM., Cao, YP., Ge, JF., Jiang, YY., Tredget, EE., Cao, MJ., and Wu, YJ.

Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin- Derived Precursors.

Stem Cell Translational Medicine. 2016.

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• Wang, S., Guo, L., Ge, JF., Yu, L., Cai, T., Tian, RY., Jiang, YY., Zhao, RC, and Wu, YJ.

Excess Integrins Cause Lung Entrapment of Mesenchymal Stem Cells. 

Stem Cells. 2015.